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This result implies that the EAF had moderate anticancer activity, and the plant might therefore be considered as an effective source of active chemopreventive agents.
The synthesized compounds showed moderate anticancer activity.
The results revealed that thiazole 11 has moderate anticancer activity against colon carcinoma (HCT-116), while thiazole 6 has less activity.
The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 μg/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 μg/ml) of stictic acid.
After 24 h incubation followed by 72 h recovery time, the two chlorido Os complexes, 1 and 3, showed moderate anticancer activity, with IC50 values of approximately 20 μ m, similar to the value obtained for the mixture of (ROs, RC)- and (SOs, RC) -[Os η- p-cym)(ImpyMe Cl]PF6 (Table 4) and significantly higher than that of cisplatin (2 μM).
Similar(54)
All the compounds showed moderate anticancer activities on MCF-7 (wild type) cancer cell lines.
The primary results showed that most compounds had moderate anticancer activities with IC50 values between 10−6 and 10−5 M.
Also, the EAF exhibited strong antioxidant and moderate anticancer activities, which were comparable to the commercial antioxidants BHT, CA and AA and the anticancer drug bleomycin.
The moderate to strong anticancer activities of the constituents of the plant have contributed to the overall cytotoxic properties of the plant extracts.
Preliminary investigations of their anticancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI50 values in the range of 13 50 µM.
16 compounds were evaluated for their anticancer activity in one-dose assay and showed moderate activity on various cell lines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com