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The deformation and fracture mechanisms of voided polymers and rubber-toughened polymers are an active research area where accurate fracture models still need to be proposed.
However, note that, even after serveral iterations, the estimators based on the SD models still need to cope with the abovementioned dependency issue.
A comprehensive literature review is needed because some related concepts are not clear and the precision of models still need to be promoted in this field.
Although strategic collaborations between corporate and academic institutions have resulted in a state of resurgence in the market, new cooperation models still need time to tell whether they will improve the translational medicine process.
However, 3D organoid models still need further optimizations such as the size and density of cell aggregates and the treatment period of NPs as well as drug-conjugated NPs [50].
Their brains are so valuable that investors are willing to take the risk on the basis of the team alone — even if the business models still need some work.
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Compared with the latest Saccharomyces cerevisiae GSMMs, the quality of these P. pastoris models still needs to be improved at least in three aspects: the balance of each reaction in mass and electrical charge, the model metabolic coverage, and the correction in GPRs.
The (improved) in vitro models still needs validation, most likely using animal data, clearly alternative approaches need to be developed for this (making use of available human data).
In addition, the applicability of the new model still need to be tested [14, 15].
Some of the details around the CNCF's governance model still need to be worked out, it seems.
Yet even with these innovative supports, the job is difficult, and many facets of the model still need improvement for teachers and students alike.
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