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Although the consistency of miRNA expression changes among serum, plasma, and tissue samples still need to be proven, it does not preclude the idea that miRNA biomarkers may serve as comparison tool for mammography as a new, inexpensive, non-invasive diagnostic tool in the future.
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The data generated with human tissue samples still needs to be validated in vivo.
In a clinical study including a control group only the ThySRQ and the ThyDQoL present QoL item are thus meaningful for group comparisons, although their use in a healthy sample still needs independent evaluation and reported results here are of preliminary nature.
Noninvasive radiological staging can aid in the initial assessment of metastatic spread but lymph node sampling will still need to be performed to determine nodal infiltration.
Nevertheless, independent sample panels still need to be investigated to confirm suspected IBS-related alterations detected in the GI microbiota.
However, conclusions drawn from our findings, based on a low sample size still need to be viewed critically.
Further studies using improved diagnostic tools and techniques, with increased sample size still need to be undertaken in order to provide a full parasite fauna occurring in cavies reared in the two breeding systems currently in place in Cameroon.
However, even when we could find functionally consistent disease signatures from currently available samples, it might still need thousands of samples to find a few reproducible individual signatures.
First, although we had adequate power to detect rs1361600 association with severe sepsis using the current data, independent samples were still needed to validate the associations.
Although several genome-wide approaches that substantially fulfill the above requirement were proposed recently, a simple and inexpensive method that enables accurate characterization of several CNVs of interest in a large number of samples is still needed.
The conclusion is that additional studies evaluating inflammatory markers in the euthymic state, ideally comparing medication-free BD patients and matched controls in large samples, are still needed in order to clarify if ongoing inflammation is a trait in BD.
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