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The involvement of AP-1 activation in our heat-stress models prompted us to ask whether the JNK pathway might also be involved.
The gender dimorphism observed in the rat and mouse MPNST models prompted us to examine the age of MPNST onset in our UCLA cohort of 113 unique MPNST patients.
The data obtained in breast cancer cell models prompted us to investigate whether ObR isoforms together with their ligand, leptin, can be coexpressed with HER2 in human breast cancer.
The presence of the MYOM3 fragments in serum of DMD and LGMD2D patients and their respective mouse models prompted us to evaluate the utility of these biomarkers for monitoring the response to experimental therapies in mdx and KO-Sgca mice.
The role of PCP signaling in the pathogenesis of NTDs in animal models and humans as well as the role of Fzd3 and Fzd6 in neural tube closure in mouse models prompted us to investigate if the human orthologs FZD3 and FZD6 genes could play a role in the pathogenesis of human NTDs, by resequencing these genes in a large cohort of patients and controls.
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The success of this model prompted us to use it to test the efficacy of the protocol we have established for infection detection using molecular biology methodology ([6],[8]; Mariani et al. 1996b; [7],[1996b1996b
The observation that Tpl2 deficiency is protective in our VILI model prompted us to examine the potential therapeutic effect of pharmacologic inhibition of Tpl2 in high VT-induced lung injury.
The data obtained in the human tumor-SCID mouse model prompted us to investigate whether the Exotest allowed the detection and characterization of exosomes purified from human plasma.
This model prompted us to perform a microarray screen to search for nuclear-enriched non-coding RNAs, using XIST's properties as a guide.
This feature of the Simplified cAMP Model prompted us to develop the Complete Model.
The presence of hornerin in each stage of the MCF10A breast cancer progression model prompted us to investigate hornerin expression in correlation to breast cancer subtype.
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