Sentence examples for models of progeria from inspiring English sources

The induced pluripotent stem cells (iPSCs) technology enables the creation of cell models of progeria and geriatrics in laboratory conditions, for studying disease mechanisms and drug screening.

The generation of mouse models of progeria has helped to unmask the molecular basis of this syndrome as well as to design therapeutic approaches aimed at improving the health span and life span of children affected.

How well do these in vitro cell culture results recapitulate the in vivo pathologies in patients and mouse models of Progeria?

In contrast, in other MSC models of progeria where MSCs were immortalized by hTeRT forced overexpression, this effect was not evident [ 27], suggesting an advantage of this MIAMI cell model and demonstrating a novel finding using our system.

Rapamycin treatment also rescues neurodegeneration in in vivo mouse models of progeria and ischemia, and in vitro models of oxygen or glucose deprivation., Thus, autophagy keeps healthy neurons from degenerating and protects neurons from damage and disease.

Several studies have shown that cells or mouse models of progeria after treatment with either farnesyltransferase inhibitor (FTI), statins, or isoprenylcysteine carboxyl methyltransferase (ICMT) inhibitor could reverse some of the phenotypic changes occurring in these cells or tissues (Fong et al., 2006; Capell et al., 2008; Yang et al., 2008; Ibrahim et al., 2013).

This could be particularly instructive in animal models of chronic diseases in which cellular senescence appears to play a role, such as in animal models of progerias or Alzheimer's disease.

Gordon says that the mouse model of progeria that worries Kennedy may not be the most accurate mimic of the human condition.

Herein we show that several downregulated miRNAs in the ERCC1-deficient mouse model of progeria are also down-regulated during normal murine aging.

We have used a progeroid model of endogenous DNA damage accumulation to identify miRNA dysregulation common to both the Ercc1-deficient mouse model of progeria and normal mouse aging in liver and kidney tissues.

For example, trimethylation of histone H4 at lysine 20 (H4K20me3), a hallmark of constitutive heterochromatin, increases in rats livers with age, and is found upregulated in a cellular model of progeria [ 26, 27].