Sentence examples for model of progeria from inspiring English sources

Gordon says that the mouse model of progeria that worries Kennedy may not be the most accurate mimic of the human condition.

Herein we show that several downregulated miRNAs in the ERCC1-deficient mouse model of progeria are also down-regulated during normal murine aging.

For example, trimethylation of histone H4 at lysine 20 (H4K20me3), a hallmark of constitutive heterochromatin, increases in rats livers with age, and is found upregulated in a cellular model of progeria [ 26, 27].

We have used a progeroid model of endogenous DNA damage accumulation to identify miRNA dysregulation common to both the Ercc1-deficient mouse model of progeria and normal mouse aging in liver and kidney tissues.

Butyrate is a general HDAC inhibitor and protects against high‐fat diet‐induced metabolic changes (Gao et al., 2009), has anti‐inflammatory properties (Maslowski et al., 2009) and extends lifespan in a mouse model of progeria (Krishnan et al., 2011) and Drosophila (Zhao et al., 2005).

Here, we describe a regulatable cellular model of progeria and show that upon induction in primary human fibroblasts, progerin leads to increased DNA damage, cellular senescence, senescence-associated reduction of lamin B1, nuclear morphology defects and altered expression of H3K27me3, in a dose-dependent manner.

The induced pluripotent stem cells (iPSCs) technology enables the creation of cell models of progeria and geriatrics in laboratory conditions, for studying disease mechanisms and drug screening.

The generation of mouse models of progeria has helped to unmask the molecular basis of this syndrome as well as to design therapeutic approaches aimed at improving the health span and life span of children affected.

How well do these in vitro cell culture results recapitulate the in vivo pathologies in patients and mouse models of Progeria?

In contrast, in other MSC models of progeria where MSCs were immortalized by hTeRT forced overexpression, this effect was not evident [ 27], suggesting an advantage of this MIAMI cell model and demonstrating a novel finding using our system.

Rapamycin treatment also rescues neurodegeneration in in vivo mouse models of progeria and ischemia, and in vitro models of oxygen or glucose deprivation., Thus, autophagy keeps healthy neurons from degenerating and protects neurons from damage and disease.