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This latter assumes an infinite-site model without recombination, requiring the removal of variants and haplotypes that violate these assumptions.

Deviations from equilibrium were tested with Fu's Fs [ 63] neutrality tests based on infinite-site model without recombination.

The method assumes an infinite-site model without recombination; therefore, haplotypes and sites that violate these assumptions need to be removed: In the case of IFI16, we eliminated 1 variant.

The test power was computed as the proportion of test statistic values falling into the lower or upper 5% tail of the null distribution (a neutral model without recombination, selection, and demographic effects).

The method assumes an infinite-site model without recombination and, therefore, haplotypes and sites that violate these assumptions need to be removed: in this case, only 2 single segregating sites had to be removed.

The variances in the denominators are evaluated exactly in the limit of short read for the standard neutral model without recombination following the results of [ 57] and accounting for the random extraction of reads from individuals.

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Watterson, G. A.. On the number of segregating sites in genetical models without recombination.

Both Fu's FS and Tajima's D use the infinite site-model without recombination to test for departures from selective neutrality and population equilibrium for intraspecific data.

Migration rate was fixed to M = 0.04 and divergence time to T = 12.5 (expected D = 135, for I and M models without recombination [ 3]).

In addition, the difference in likelihood between models with and without recombination for each sequence was also assessed, with the statistical significance of the improvement of recombination models over those without as P < 1 × 10-32.

We therefore added exponential growth (α = 25) to each subpopulation in the Wright island model with 100 demes without recombination.

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