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The DAPA flux kinetics, with and without ammonium chloride, was well fitted by a reaction-diffusion model with reversible cellular uptake (modelled as binding), using uptake parameters determined in separate experiments with V79-171b single-cell suspensions.
Therefore, a process model consisting of a continuous stirred tank reactor model with reversible Michaelis Menten kinetics for representation of EMR operation, a transport-dispersive true moving bed model for representation of SMB operation and an ideal filtration model was constructed.
We enriched the model with reversible and irreversible tissue damage, which aims to provide a comprehensible link between autoimmune activity and clinical relapses and active lesions in the magnetic resonances studies in patients with Multiple Sclerosis.
We verified the results for strong selection using a theoretical formula for the distribution of gene frequencies in a panmictic population under a two-allele model with reversible asymmetric mutation and one selectively favored allele (supplementary fig. 1; supplementary text, Supplementary Material online).
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For instance, mutagenic deaminating agents cause substitution biases (G → A, C → T) that cannot be accurately modeled with reversible substitution models [ 44].
As these products can react with each other to reform the substrate [ 31], we wondered how the reciprocal plot data would be affected if the reduction of the glutathionylated substrate was modelled with reversible kinetics.
The BTCs in both soils were described well by a model with one reversible (kinetic) and one irreversible sorption site.
The resulting multilevel model is fit with reversible jump Markov chain Monte Carlo (RJMCMC) to obtain posterior distributions for the number of sources and their individual parameters.
In this experimental model of CPB with reversible MCAO-induced focal cerebral ischemia, hemodilution worsened neurological function and increased cerebral infarct volume.
We used the Bayesian skyride model (18 ) as a flexible tree prior and a general time-reversible model with a discretized gamma distribution (general time-reversible + 4Γ) to account for among-site rate variation.
Metastases TACs were noisy and thus described adequately by several models, with the most appropriate being a one-tissue compartment model for reversible binding, with PET V T estimates ranging from 0.16 to 1.03 with no significant differences in V T or K 1 (the other model parameter) between baseline and day 8 scans.
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