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Fig. 4 a c Activation/repression pathway diagram and state transition diagrams corresponding to a constant input dna_dsb = 0 (no-stress) and dna_dsb = 1 (DNA-damage) for the P53-MDM2 negative-feedback loop Boolean network model with negative regulation biases.
*Estimated with a generalised linear random effect regression model with negative binomial link function.
For example, any model with negative feedback loops cannot be used to construct an aggregated HYP.
10.7554/eLife.11611.028 Author response image 2. Competition in a model with negative feedback.
Thus, the ERK cascade model with negative feedback seems to be the most consistent with our experimental observations over a wide range of parameter values.
Surprisingly, we find that a simple MAPK/ERK-cascade model with negative feedback that displays graded, analog ERK responses at a single cell level can explain the experimentally observed bimodality at the cell population level.
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Friedmann also introduced cosmological models with negative curvature.
The crime-generating and crime-attracting characteristics of stations are modeled with Negative Binomial Regression analysis.
Situations where the larger part of the users need to maintain a high bit rate connection with the access network can be modelled with negative values for α.
A set of generalized linear models with negative binomial error structure is developed to correlate the simulated conflicts with the observed crash frequency in Toronto, Ontario, Canada.
Therefore, Homo sapiens and Gorilla gorilla were used as positive data to create models with negative data coming from species from the Pisces class or Nematoda genus (Tables 2 and 3).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com