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The three parameters were estimated by fitting a Bayesian statistical model to plasma insulin data (ESM Methods).

F a ·F g is also estimated using a previously published noncompartmental method to compare with the value estimated from fitting PBPK model to plasma data.

An empirical amplification parameter, γ, was added to the input of the final differential equation, dCRP3, in order to better fit the model to plasma CRP data.

Silibinin binding parameters were obtained from the literature; clearance parameters were generated by fitting the PBPK model to plasma concentration time data from hepatitis C patients receiving silymarin (Table 3 ).

CL act, tot is modeled as the sum of CL act, OATP1B1 and CL act, other : The nongenotyped CL act, tot, CL bile, CL pass, k a, F a ·F g were estimated by fitting the model to plasma concentration time course data following intravenous infusion and oral dosing in nongenotyped studies.

Similar(54)

To evaluate the ability of the Schnider pharmacokinetic model to predict plasma propofol concentration during target-controlled propofol infusion in patients with impaired left ventricular function and to investigate the predictive value of the bispectral index (BIS) to indicate deep sedation in this patient group.

In contrast, a different study of young (ages 19-36) and older (ages 47-73) men used a hyperinsulinemic clamp model to measure plasma glucose clearance.

To evaluate the impact of vitamin D status after a diagnosis of colorectal cancer in a larger number of patients, we developed a model to predict plasma 25(OH D levels.

Table 2 shows the results of Type III test of propensity score-weighted linear mixed effect models fitted to plasma TG, TC, HDL-C and LDL-C data.

Table 3 shows the results of Dunnett's multiple-comparison test of propensity score-weighted linear mixed effect models fitted to plasma TG, TC, HDL-C and LDL-C data.

The ability of the developed models to recover plasma concentrations of ethambutol, pyrazinamide, and isoniazid were checked by comparing predicted plasma concentrations with published data using similar study designs and subject demographics (Supplementary Table 1).

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