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The 13 days exposure was used to model the chronic response of kidney to environment of cadmium exposure.
We hypothesized that repeated exposure to TBHP would model the chronic oxidative stress previously associated with AMD [ 22].
They chose to model the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation and therefore better understand the kinetics of cardiac tissue regeneration.
To do this, we used bivariate logistic regression models with the sandwich variance estimator to model the chronic LBP and radicular symptom outcomes simultaneously, while accounting for clustering of these two outcomes on the level of the individual participant [ 25].
The hypothesis on which we are currently working on, is that in this animal model the chronic ischemia induces an overexpression of beta3-ARs on vascular endothelial cells, which in turn could stimulate the activation (cross-talk) of beta2-ARs (data still unpublished).
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For designing such integrated care models, the Chronic Care Model (CCM) [ 15] provides a solid and evidence based framework, as acknowledged by the World Health Organization [ 16].
One well-known model is the Chronic Care Model (CCM) [ 20- 23], which maps out chronic illness management activities in terms of six components: healthcare organization, service delivery systems, community resources, self-management support, decision support systems, and clinical information systems.
Many case management organisations in the Netherlands are modelled after the chronic care model.
In model 1, the chronic stressors in aggregate accounted for approximately 7% of the variance in AL scores, after accounting for covariates.
The time points of this study were chosen as models of the chronic progressive nature of complications such as DR and are consistent with previous studies [ 14, 19].
Heart failure care models inspired by the chronic care model, also known as heart failure programs or heart failure units, have shown clinical benefits in high-risk patients.
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