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In this animal model, the bone formation can be initiated before 15 days, as has been seen in other studies, but it is very spars.
These drawbacks prevented us to verify whether in this model the bone response and the tumor growth induced by the Nog-KD clone progress equally to those observed in the intra-osseous model.
However, in the ACLT model, the bone volume fraction and trabecular thickness were clearly reduced.
Originally developed as a rat model, the bone conduction chamber was adjusted for use in goats [ 34].
For the stemmed model, the bone stock above the neck was obliquely removed and the stem was instrumented into the intramedullary canal, same as in traditional stemmed THR.
Due to the low number of animals in the groove model, the bone parameters could not reach statistical significance in this model.
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However, in an experimental canine model, the bone-healing index showed that new bone consolidation was best with zero-day latency in metaphyseal and diaphyseal lengthening [13].
In the current implementation, this is achieved using a lookup table, but faster implementations are certainly possible (e.g., modeling the bone and soft tissue clusters as ellipsoids).
The potential clinical relevance of antitumor activity of S-222611 was confirmed with two important patient-oriented models: the "bone metastasis" model and "brain metastasis" model (Fig. 3a e).
When local bone compaction around the helical blade is modelled, the bone area immediately superior to the helical blade shows no susceptibility to yielding.
This is in accordance with other studies that have modeled the bone matrix as a mineral continuous phase reinforced with "compliant" collagenous fiber inclusions [48,49].
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