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S. aureus (ATCC 6538P) was used as the model of pathogenic bacteria.
Importantly, this cellular protection was reproducible in the more prognostic ferret model of pathogenic influenza infection, demonstrating for the first time significant protection from weight loss and viral shedding.
This was later generalized to a more basic model of pathogenic bacteria.
and M. tuberculosis (A. C. Helguera-Repetto et al)., and biofilm formation (H. F. Culler et al).; a model of pathogenic E. coli in ameba (F. Yousuf et al).. Angel Cataldi Ana Lucia Nascimento Armando Acosta Chensong WanWAngel Cataldi Ana Lucia Nascimento Armando Acosta Chensong Wan
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NHP models of pathogenic SIV infection closely recapitulate pulmonary lesions observed in HIV-infected patients.
A number of studies successfully applied these methods for different biological purposes, e.g. modelling of immune diseases [ 10, 13], full genomic models of Escherichia coli [ 8] and Saccharomyces cerevisiae [ 18], and models of pathogenic fungi [ 16].
Network inference reverse engineers regulatory networks with the help of high-throughput data and has been successfully applied in a number of studies ranging from immune diseases [ 1, 2], full genomic models of Escherichia coli [ 3] and Saccharomyces cerevisiae [ 4, 5] to models of pathogenic fungi [ 6].
Therefore, the validation of these strain-specific metabolic models for carbon source utilization will prove useful for future computational modeling of pathogenic E. coli strains in conditions encountered in the gastrointestinal tract or in other locations such as the urinary tract in mammalian hosts.
Mass spectral peaks that pertain to the neural network classification model of the pathogenic bacterial classes were obtained by sensitivity analysis.
We thus used a model of experimental pathogenic infection in cynomolgus macaques a well-known, suitable model that reproduces long-lasting HIV-1 disease [22] to investigate B-cell dysfunctions during acute HIV infection.
A study by Willing et al nicely employed how different mouse strains exhibit varying susceptibility to Citrobacter rodentium (a model of human pathogenic E. coli infections).
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