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NHP models of pathogenic SIV infection closely recapitulate pulmonary lesions observed in HIV-infected patients.
A number of studies successfully applied these methods for different biological purposes, e.g. modelling of immune diseases [ 10, 13], full genomic models of Escherichia coli [ 8] and Saccharomyces cerevisiae [ 18], and models of pathogenic fungi [ 16].
Network inference reverse engineers regulatory networks with the help of high-throughput data and has been successfully applied in a number of studies ranging from immune diseases [ 1, 2], full genomic models of Escherichia coli [ 3] and Saccharomyces cerevisiae [ 4, 5] to models of pathogenic fungi [ 6].
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S. aureus (ATCC 6538P) was used as the model of pathogenic bacteria.
Importantly, this cellular protection was reproducible in the more prognostic ferret model of pathogenic influenza infection, demonstrating for the first time significant protection from weight loss and viral shedding.
This was later generalized to a more basic model of pathogenic bacteria.
and M. tuberculosis (A. C. Helguera-Repetto et al)., and biofilm formation (H. F. Culler et al).; a model of pathogenic E. coli in ameba (F. Yousuf et al).. Angel Cataldi Ana Lucia Nascimento Armando Acosta Chensong WanWAngel Cataldi Ana Lucia Nascimento Armando Acosta Chensong Wan
Therefore, the validation of these strain-specific metabolic models for carbon source utilization will prove useful for future computational modeling of pathogenic E. coli strains in conditions encountered in the gastrointestinal tract or in other locations such as the urinary tract in mammalian hosts.
Accumulation of enteric viruses on surfaces within a drinking water distribution system was investigated in a reactor using three F-specific RNA bacteriophages (MS2, GA, and Qβ) as models of human pathogenic viruses.
Table 2 presents the AUC of models for pathogenic mutation and Table 3 the Pairwise comparison of ROC curves for MMR germiline mutation.
Both sooty mangabeys and African green monkeys, the most well-studied models of non-pathogenic SIV infection, down-modulate SIV entry receptors on important immune cell populations to protect them from infection and preserve long-term immune function.
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