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This study was designed to elucidate profibrotic signaling and myofibroblast activation in a porcine model of atrial tachypacing-induced AF and reduced left ventricular function.
It was reported that mRNA and protein of TRPC1/3 channels were upregulated in human atrial tissue with atrial fibrillation and a goat model of atrial fibrillation [ 47].
The developed cell model is implemented in DEM by using a clump of nine particles, representing atrial cellular geometry; (ii) a 2D DEM tissue model of atrial tissue was developed with consideration of atrial anisotropic and discrete natures.
Atrial NO synthesis is reduced in a porcine model of atrial fibrillation [ 75], and atrial production of superoxide and peroxynitrite is correlated with risk of developing atrial fibrillation in patients undergoing cardiac surgery [ 76].
This work has been extended in a canine model of atrial fibrillation in which researchers have observed that discharges from the stellate ganglia and vagal nerves often precede the onset of paroxysmal atrial fibrillation (19).
Using the tissue model, the conduction of cardiac electrical waves and the corresponding mechanical contraction were simulated; and (iii) a numerically stable algorithm was developed to solve the DEM model of atrial tissue.
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The promising efficacy of several new drugs in animal models of atrial fibrillation has yet to be demonstrated in clinical studies.
Here we review an array of the rabbit models of atrial and ventricular arrhythmias, as well as a range of the imaging and device technologies enabling these investigations.
Aidonidis et al. recently investigated right atrial monophasic action potentials in a rabbit model of inducible atrial tachyarrhythmias in vivo using intracardial catheters.
Koivumäki et al. [ 20] integrated these electrophysiological findings into a mathematical model of human atrial myofibroblasts [ 21].
Limited data are available from a study by Cai et al., conducted in a pig model of rapid atrial pacing.
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