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However, in our capsaicin model, injection of the trkB-IgG fusion protein (an inhibitor of BDNF function [64]) into the area of secondary hyperalgesia (10 µg/50 ul, 4 h prior to capsaicin injection) had no effect on pinprick pain thresholds compared to vehicle controls (data not shown).

In this well characterized model, injection of the cytotoxin streptozotocin (STZ) results in a reduction in ß-cells and an increase in plasma glucose to diabetic levels [ 4].

In a similar series of experiments using the same rat ROP model, injection of anecortave acetate also reduced VEGF protein at one and two days post-oxygen exposure.

In the DT-22 model, injection of 100,000 cells of each cell type failed to yield metastasis when tumours were excised at 1 cm and animals followed for a further 10 months.

In vitro F XIII caused a dose-dependent enhancement of array formation in a Matrigel tube formation model, while in a rabbit cornea model, injection of F XIII led to neovascularization [ 28].

In a different model, injection of DTA-1 8 days after the inoculation of BALB/c mice with a methylcholanthrene-induced fribrosarcoma produced tumour-specific immunity (Ko et al, 2005).

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Mice were first subjected to malignant tumor inoculation by either subcutaneous (model of local tumor) or intravenous (metastatic model) injections of the MCA205 fibrosarcoma cell line.

In orthotopic glioma models injection of NSCs transduced with the gene for cytosine deaminase led to a strong reduction of tumor burden [ 1].

In the most common experimentally induced models, injection of adjuvant and various joint matrix components, such as collagen type II or proteoglycan aggrecan, causes autoimmune arthritis in susceptible inbred mouse strains [ 28, 29].

In this model, injection rate and time of injection are assumed based on the previous fracture jobs in the area.

Warfarin inhibits metastasis in the animal model and injection of the Warfarin-dependent coagulation factor complex II, IX, X enhances pulmonary metastasis in the same model.

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