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Here we developed a novel computational multi-tissue model for recapitulating the dynamic systemic distributions of VEGF and sVEGFR1.
In summary, the goals of this study were: (1) to develop a computational multi-tissue model for recapitulating the systemic distributions of VEGF and sVEGFR1; (2) to parameterize the model for a healthy human subject; and (3) to investigate the effects of sVEGFR1 and lymphatic drainage on the VEGF ligand-receptor system.
Overall, using DMD patient-derived iPSCs, this study establishes a novel in vitro model for recapitulating disease phenotypes, studying molecular disease mechanism and future preclinical testing of novel therapeutic compounds for dilated cardiomyopathy in DMD patients.
Thus, this study aimed to determine whether transgenic Göttingen minipigs could be used as an animal model for recapitulating features of familial APPsw AD by overexpressing either a single copy or two copies of the human APPsw gene in these animals.
Freshly isolated primary hepatocytes are the preferred cell model for recapitulating the functional responses of the liver, especially for in vitro studies to predict in vivo drug metabolism and clearance (Lin, 2006 Hewittt et al., 2007b; Hewitt et al., 2007c; Gómez-Lechón et al., 2008; Obach, 2009).
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Both the results presented here as well as those described in earlier studies confirm that CH1 cells represent yet another good model system for recapitulating BCR-driven responses in immature B cells.
Use of the chromosomal engineering mouse model is important for recapitulating human chromosomal abnormalities such as large deletions, inversions, and translocations.
We find that the new SCT mouse model for XXY and XYY recapitulates features found in humans with these aneuploidies.
These cell models provide a powerful translational in vitro approach for recapitulating human ARDS.
Here we report the development of a fully orthotopic, humanized in vivo model for melanoma, faithfully recapitulating human disease initiation and progression.
Therefore, a more relevant model system recapitulating human XP pathogenesis is needed for studying the disease mechanism and developing related therapy.
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