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Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes.
In this paper, we propose a new method based on Laws' microtexture energies and maximum a posteriori (MAP) estimation to construct a probabilistic deformable model for kidney segmentation.
In the present study we induced uraemia in the recently established mouse PD exposure model in order to obtain a more clinically relevant mouse model for kidney patients.
A more precise dose-volume response model for kidney will not only improve our current understanding but may permit further optimisation of radiation therapy techniques for upper-abdominal tumours.
Well, unfortunately, mice are not an ideal model for kidney disease: although they do develop certain features of both chronic kidney disease and diabetic nephropathy, they don't develop the full spectrum of the disease.
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During that period, my lab was part of a consortium to develop 'human-like' mouse models for kidney diseases.
However, the excretory cells in these two species do not have cilia, which has limited their use as models for kidney disease.
This article focuses on the various models for kidney toxicity due to trichloroethylene (TCE) and its glutathione-dependent metabolites, in particular S- 1,2-dichlorovinyl -l-cysteine.
As to molecular investigations based on the use of diverse cell culture models for kidney epithelial cells, there is some discrepancy between results obtained upon overexpression of PLCN-1 in two different kidney epithelial cell lines used.
The negative regulatory role of BMP in TGFβ signaling has been demonstrated in several models, for example in the murine model systems for kidney disease [38] and in mouse pulmonary myofibroblast [39].
The competing-risk model allows for death to be correlated with kidney disease progression; in other words, the fitted model allows for kidney disease progressors to have a higher mortality risk.
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Justyna Jupowicz-Kozak
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