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The heterogeneous distribution of mobile elements has impacted the diversification of O26:H11 more than other EHEC 2 serotypes.
Current knowledge of distribution and evolution of this group of mobile elements has been mainly obtained from diverse model organisms [ 3].
Some large scale gene sharing between very different mobile entities (i.e., viruses and capsidless mobile elements) has recently been described elsewhere (Desnues et al. 2012; Yutin et al. 2013) giving rise to the concept of a mobilome network.
This independent acquisition of genes mediated by various mobile elements has also been reported in EcO157 and EcO55, leading to a variety of genomically related strains with distinct bacteriophage collections [ 29].
Exposure of organisms to high pressure has resulted in such mobilisation of transposable elements (Aertsen & Michiels, 2005; Lin et al., 2006), and alteration of methylation patterns of mobile elements has also been reported following hydrostatic pressurisation (Long et al., 2006).
Therefore, recombination induced by mobile elements has an additional role, increasing effectiveness of the purifying selection in bacterial genomes, which is beneficial for the host genome evolution [ 52, 53].
Similar(51)
As a consequence of this pressure, phages and mobile elements have evolved 'anti-CRISPR' proteins that function as direct inhibitors of diverse CRISPR-Cas effector complexes.
The vast majority of these mobile elements have deleterious effects on the host genome, because of the gene mutations and chromosomal rearrangements they promote, and usually they are efficiently eliminated by selection [2].
Mobile elements have been extremely successful at colonizing human genomes.
Mobile elements have shaped both genes and entire genomes [ 7].
This would imply that the same mobile elements have mediated different rearrangements in these two organisms.
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