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The condition (3) is similar in form to the persistence condition for mobile elements given by Lynch [ 66].
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Mobile elements make up ∼45% of the human genome [1].
Mobile elements have shaped both genes and entire genomes [ 7].
Mobile elements have been extremely successful at colonizing human genomes.
In this study we show that the key XIC gene Xist, which displays fragmentary homology to a protein-coding gene Lnx3, emerged de novo in early eutherians by integration of mobile elements which gave rise to simple tandem repeats.
Mobile element insertions give a variety of unexpected behaviours in such analysis.
Indeed, the R. prolixus mobilome (all the mobile elements in a given genome) is largely dominated by DNA transposons that represent 75%% of the mobilome, whereas in B. mori, Drosophila species, T. castaneum and A. gambiae, retrotransposons and their derivatives are considerably more prevalent (respectively 89 %, 67%to93 93 %, 87 % and 72 %) [ 24– 27].
The persistence of a mobile element in a given population is thus the result of a delicate balance between an excessive mutational burden on the host caused by the element's unrestricted activity, and excessive negative regulation imposed by the host on the element to limit mobility.
Indeed, since the insertion of a mobile element in a given position of the genome is a rather unique event, the presence in the same genomic position in different homologous regions can be used to infer a common origin [ 32, 33].
Mobile elements might have allowed HGT and/or recombination events.
Moreover we have found that many Xist exons originated from mobile elements of various classes, which gave rise to simple tandem repeats detectable in the structure of the gene.
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