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Exact(6)
Sensitivity analysis was performed by excluding patients with missing baseline creatinine.
Secondly, the handling of missing baseline creatinine values may confound results.
Sensitivity analysis by excluding patients with missing baseline creatinine was performed, and the results remained unchanged (data not shown).
We recommend calculating AuROC for AKI based on patients not fulfilling AKI criteria on entry and applying ADQI recommendations when missing baseline creatinine value obtained prior to admission.
The proportion of patients with missing baseline creatinine should be stated, and a sensitivity analysis excluding these patients would be desirable.
Missing baseline creatinine was imputed using the MDRD formula and an eGFR of 75 mL/min/1.73 m2 [9].
Similar(54)
The handling of missing baseline values varied: some used admission creatinine, some used back calculating with the Modification of Diet in Renal Disease (MDRD) formula, and one study used multiple imputation.
For the 44 cohorts with data from both women and men, subjects with missing baseline values for estimated glomerular filtration rate or urinary albumin-creatinine ratio or dipstick tests were excluded.
For patients with missing baseline demographics (height [ n = 35], body mass index [ n = 35], creatinine clearance [CrCL] [ n = 13], and body weight [ n = 13]), median values of the population were used.
Several different approaches have been suggested to compensate for a missing baseline value including estimation of a glomerular filtration rate (GFR) based on population norms [6], use of the nadir creatinine during hospitalization as baseline; however, these have all been found to result in over- or underestimation of AKI [7].
We excluded re-admissions and cases with missing baseline data.
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