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Exact(6)
The largest series showed a CT partial response of 28%% and a minor response of 16%% [ 9].
Target lesions were enlarged lymph nodes in the mediastinum and retroperitoneum, and after 8 weeks of TB-403 a minor response of 25% was observed (best response s.d).
One patient continued on CC-5013 at 50 mg for 8 months during which time there was a minor response of pulmonary secondaries.
At the time of this report, seven out of fourteen patients had stable disease, two patients had a 30% decrease in serum tumor markers, and one minor response of a metastatic kidney cancer patient was noticed [ 69].
Graphical representation of the same data (Fig. 3C) emphasizes the relatively minor response of airway epithelial cells and the differential response of macrophages and monocytes to LPS and APM in terms of the magnitude of pathway involvement.
Surprisingly, given the poor chemosensitivity of chordomas, there was also an initial minor response of the sacral tumour, which was lost soon after, but then was restored with the resumption of Imatinib (the plan was to reintroduce the latter in combination with cisplatin, but renal function did not allow it).
Similar(54)
Despite the fact that clinical response was not the primary end point of the study and that the patients had not responded to prior therapy, we found clear evidence of drug activity in rapidly progressing malignant melanoma with one PR and two minor responses of visceral disease.
All six (100%) cases of tau-negative expression showed a favourable response (partial response or minor response) to Paclitaxel administration.
Phase II trials for renal cell carcinoma yielded an objective response rate of 5 7%, a minor response rate of 26 29%, and stable disease in approximately 40% of the patients (Atkins et al, 2004).
A pooled analysis of pivotal phase II trials in pretreated advanced soft-tissue sarcomas demonstrated an objective response rate of 9.4% and an additional minor response rate of 8.7%, a 1-year survival of 40% and a progression-free survival at 6 months of 27% (Le Cesne et al, 2001).
The overall response rate was 50%, with a minor response rate of 25%, both inferior to a study of thalidomide/rituximab by the same authors.
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