The largest series showed a CT partial response of 28%% and a minor response of 16%% [ 9].
Target lesions were enlarged lymph nodes in the mediastinum and retroperitoneum, and after 8 weeks of TB-403 a minor response of 25% was observed (best response s.d).
One patient continued on CC-5013 at 50 mg for 8 months during which time there was a minor response of pulmonary secondaries.
Graphical representation of the same data (Fig. 3C) emphasizes the relatively minor response of airway epithelial cells and the differential response of macrophages and monocytes to LPS and APM in terms of the magnitude of pathway involvement.
At the time of this report, seven out of fourteen patients had stable disease, two patients had a 30% decrease in serum tumor markers, and one minor response of a metastatic kidney cancer patient was noticed [ 69].
Surprisingly, given the poor chemosensitivity of chordomas, there was also an initial minor response of the sacral tumour, which was lost soon after, but then was restored with the resumption of Imatinib (the plan was to reintroduce the latter in combination with cisplatin, but renal function did not allow it).
Both acyltransferases showed no or minor responses to Ca2+, despite the presence of a calcium binding EF-hand region in AtLPEAT2.
Analysis of survival in relation to response suggested that monitoring of minor responses may be of interest for biological agents such as interferon.
Evaluation of tumour response at the injected tumour sites showed that three of the 22 patients (14%) experienced objective, partial, tumour responses and an additional ten patients (45%, including two minor responses) showed stabilization of their disease.
A recent Phase I trial showed that systemic administration of SS1P, a recombinant-targeted toxin similar to EGF4KDEL 7Mut, resulted in stable disease or minor responses in 14 of 19 patients with MM (Hassan et al, 2007).
