Sentence examples for minor binding from inspiring English sources

Studies have shown that the N-terminal "KR" motif of bipartite NLSs binds the P1' and positionsiofs of the minor binding site in importin α, while the larger "KRRK" motif binds the P2 P5 positions of the major binding site in importin α [36] (Fig. 8A).

minor binding saccharides.

In addition, one or two other adjacent saccharides also participate in binding to the surrounding regions of the CBP as minor binding saccharides (MiBS) to strengthen the binding forces.

The NMR structures and Autodock analysis suggest that the pocket with the most favorable amphipathic property for anesthetic binding is located between the W15 side chains at the center of the dimeric hydrophobic core, with the possibility of two additional minor binding sites between the F12 and F52 ring stacks of each monomer.

Representatives from the government, activist groups, and manufacturers had convened at the BGMEA's headquarters in Dhaka and at one point discussed a draft proposal that would have instituted some relatively minor binding standards for fire safety in local factories.

On the other hand, the non-overlapping binding sites were the minor binding sites as it was judged by the low-level enrichment.

When "G" (AAA GTTT) is substituted by "I" (inosine) (AAA ITTT) at the minor groove binding site, the binding affinity decreases by 30-fold (KD = 10 nM) as would be expected for disruption of hydrogen bonding between the azabenzimidazole and G- NH2.

The detailed thermodynamic and kinetic analyses reveal that, like other DNA minor groove binding organic small molecules, the binding enthalpy, entropy, and free energy of the DB2277 AAA GTTT complex highly depend on the experimental salt concentrations and the temperatures.

The additional α-methyl group at the intercalating proline significantly disturbs the β-sheet conformation of the minor groove binding loop thereby completely interrupting DNA binding.

Second, STAT1 does not bind only the major and minor NLS binding grooves of importin α5, but requires importin α5 C-terminal Armadillo repeats (ARM) 9 and 10 for high affinity binding [ 46].

Combilexin molecules, which combine DNA minor groove binding and intercalating functionalities, have the potential for increased DNA binding affinity and increased selectivity due to their dual mode of DNA binding.