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By combining RNA-Seq of three current cultivars (Atlantic, Premier Russet, Snowden) with data mining of existing ESTs from three older cultivars (Bintje, Kennebec, Shepody), we were able to identify an abundance of SNPs in elite potato germplasm.
Another approach to mining molecular markers, involving in silico methods, has also been successful; examples include the derivation of markers from a draft genome [ 12] and the mining of existing expressed sequence tag (EST) libraries [ 13].
These efforts have generally fallen within two categories: (1) the creation of hybrid promoters that respond to different classes of known transcription factors, and (2) the genomic mining of existing parts from various organisms for use within a particular host.
Interestingly, a high-throughput electronic-biology approach based on in silico data mining of existing databases and integration of this information has been proposed for drug discovery and repurposing.
This sequence diversity of the potato genome has been long documented through the characterization of SNPs in its transcriptome, either by bioinformatic mining of existing expressed sequence tag databases [ 9, 10] or by active sequencing of cDNAs and selected genes in cultivar panels [ 11- 13].
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We need to declare a moratorium on any new coal, oil or gas mining and expansions of existing mines.
Our paper aims to encourage those research scientists which do not have extensive programming and data mining knowledge to take advantage of existing data mining tools, to embrace classical data mining and LOD approaches in support of gaining more insight and recognizing patterns in highly complex data sets.
Finally, for potential small molecule targets, we mined extensive databases of existing small molecule inhibitors and their targeting proteins.
Therefore, we performed a second benchmark to assess the validity of the candidate gene predictions using text mining of the existing Pubmed literature for CAD.
The relationship between leadership and quality of care needs multidimensional innovative research using e.g. data mining of large existing data pertaining to these topics [ 38].
This study involved the mining of an existing data set collected by Ipsos MORI who adhere to a code of conduct that encompasses ethical and legislative principles in the UK.
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