Sentence examples for minimum effective concentrations from inspiring English sources

However, these parameters can only be used to compare different formulations of the same triptan, and not different triptans, since data about the time-course of plasma concentrations in connection with the dose and response are missing, and we do not know the minimum effective concentrations of oral triptans which have different potency.

Comparison of minimum effective concentrations showed caspofungin to be significantly more active against the E. nidulans isolates (p<0.05).

They define NTIDs as those having less than a twofold difference in the minimum toxic concentrations and minimum effective concentrations in the blood and those for which specific drug treatment control fees are approved as remuneration for treatment [ 32].

Figure 3A shows the frames of the chemotaxis (performed on the EZ-TAXIScan) induced by different molecules at 0, 5, and 10 min to determine the minimum effective concentrations of the fMLF derivatives.

Minimum effective concentrations of all treatments (hyaluronan, 100 μg/ml; monoclonal anti-human MIF antibody, 50 μg/ml; anti-sense MIF mRNA, 200 ng/ml); resulted in a small but significant reduction in cell numbers 24 h post-treatment and 48 h post-treatment when compared to untreated control cells (Fig. 2B, p < 0.01).

It has been reported as a narrow therapeutic index drug that may cause severe nephritis and neurotoxicity at high concentration and fails to produce pharmacological effect below minimum effective concentration [ 13].

Analgesic effect is related to serum drug concentration; the minimum effective concentration (MEC) defines the level of serum drug level required to provide analgesia [ 19].

Based on pharmacokinetic (PK) and pharmacodynamic (PD) analyses, a model that quantitatively explains the in vivo effects of ECyd was proposed, using the concept of minimum effective concentration.

However, an improved correlation between in vivo activity and the minimum effective concentration (MEC) – the lowest dose of drug that causes morphologic effects on fungal hyphae – was observed [ 12].

Because of these fluctuations in drug plasma levels, the drug concentration could fall below the minimum effective concentration or exceed the minimum toxic concentration.

Background and Objectives: Whether patients titrate themselves to an individualized blood or plasma opioid concentration (the so-called minimum effective concentration or [MEC]) has been debated extensively.