In contrast, what we found is that the DAF<0.1 variations appear largely adaptive in human populations because the maintenance of an optimal minimal intron length results a better functionality (efficiently processed and exported to the cytosol) for minimal intron-containing genes.
Fasta sequence was mapped to the human hg19-genome sequence using the Genomic Mapping and Alignment Program (GMAP) and a minimal intron length of 25 (–minIntronlength = 25).
However, the length distribution is frequently characterized by at least one distinct mode commonly below 100 bp: These putative optima for minimal intron length vary between species.
In contrast, short introns in nonrecombining autosomal regions are slightly smaller than in autosomal recombining regions, which could be due to relaxed selection on minimal intron length for correct splicing (Comeron and Kreitman 2000).
Very short introns with lengths below 60 nt warrant a special consideration (Parsch 2003): The boundaries on the minimal intron length lead to extra selection against deletions in this length class.
In the literature, the minimal intron length is usually given as a range, an average or as a length lesser than a certain number, often without a primary reference, accession number or gene name.
