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The minimal hit length was set to 100 nucleotides.
GO terms were assigned to the sequences using Blast2GO [ 44] with an E-value cutoff of 1E-25 and a minimal hit length of 80 amino acids.
In short, the identification of similar sequences relies on parameters defining relevant hits (based on e-value, identity thresholds in the aligned regions, minimal hit length), and on parameters tagging the hit quality (such as best-reciprocal hit, minimal length coverage represented by this hit over each of the compared sequences).
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All BLAST hits were filtered with an E-value cut-off of 10−5 and hit length of ≥50 bp.
Moreover, there exist a strong relationship to minimal hitting sets known from set theory: the MCSs are the minimal hitting sets of the collection of target modes and vice versa.
All minimal hitting sets for the NCI60 system.
Specifically, we may obtain different estimated minimal hitting set sizes and/or different hitting sets with the same size.
The latter problem is mapped to the minimal hitting set problem in mathematics.
The list of drugs in the minimal hitting sets reported in Table 1.
Having constructed the strain-drug response graph we proceed to identify minimal hitting sets.
Yet, using current heuristic algorithms we can estimate the size of the minimal hitting set [ 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com