Sentence examples for minimal affinity for from inspiring English sources

The development of new protease inhibitors with high potency, low susceptibility to mutations and minimal affinity for unwanted targets is an urgent goal.

The first was the development of the primer pair ENDOITSf and ENDOITSr (Table 1), created by comparing alignments of Atriplex ITS sequences against the ITS sequences of fungal isolates, and identifying potential fungal primers with minimal affinity for Atriplex DNA.

Notably, a mutant CXCL12 sequence has been designed that has minimal affinity for HS (18).

In addition, the 25T linker alone showed minimal affinity for Ang2.

CBG binds physiological glucocorticoids (cortisol, corticosterone) with high affinity, but has low or minimal affinity for their inert 11-keto-forms (cortisone, 11-dehydrocorticosterone) or for synthetic glucocorticoids (dexamethasone, prednisolone, triamcinolone) or mineralocorticoids (aldosterone, deoxycorticosterone, fludrocortisone) [26,229].

Muscimol is a potent synaptic and extrasynaptic GABAA receptor agonist that promotes GABAA receptor desensitization to the same extent as GABA (Mortensen et al., 2010), but displays minimal affinity for plasma membrane GABA transporters (Johnston et al., 1978).

In general, a minimal affinity between self-MHC:self-peptide complexes and the TCR appears to be an important factor for the function T cells [32].

However, a critical difference between epothilones and other bulky natural products or derivatives is that overexpression of ATP-binding cassette (ABC) transporters does not significantly alter the cytotoxicity of epothilones, as these congeners have minimal substrate affinity for these proteins [ 25].

Therefore, we can conclude that molecular shape has minimal influence on affinity for this series of compounds since the most potent ligand is different from spipethiane in shape but similar to the least potent ligand.

His first album since 2002, Scene Delete (out April 1 on CD and 3xLP), flexes Coe's affinity for minimal compositions, and sees him collaborating with Radiohead member Nigel Godrich's band, Ultraísta, British artist John Graham, as well as ThermalBear, on a variety of tracks built more for your headphones than the peaking dancefloor.

Although MMP-1 and MMP-3 are known to cleave MCP-1, −2 and −4, the antagonistic effects of the cleaved products on inflammation are minimal, because of lower affinity for the chemokine receptors [ 37].