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Each of the constructs showed modest affinity for immobilized HA.
During our investigations, it became apparent that the neutral antagonists identified so far had all modest affinity for the receptor.
This suggests that any DSM, with even modest affinity for one of the signaling proteins in this limited list, has the potential to transactivate other signaling pathways to create interlocking pathways capable of linking neurogenesis to nutrient sensing.
The latter also has modest affinity for propionate [ 32].
L-SPD also had modest affinity for D2 receptor and serotonergic 5-HT1A receptor.
12Y-2, hasever, has only a modest affinity for AMA-1 in the order of 358 nM (KD) making it an ideal candidate for affinity maturation.
Similar(47)
The Tomlinson library has been used in the past for antigens and has contained antibodies with both strong and modest affinities for the targets.
Furthermore, the relatively modest affinity of single UIM for monoUb leaves open the possibility that the mechanism of high-affinity binding may involve cooperation between multiple UIMs [14], [15], [45] and polyUb chains [46], [47].
Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.
Beginning with a library of oligomers comprised of peptoid and peptide tertiary acid (PTA) units, we report the identification of a modest affinity ligand for matrix metalloproteinase 14 (MMP-14), a potentially interesting target for slowing tumor metastasis.
NMOP6 (Neuromyelitis optica peptoid 6) is a peptoid isolated from one of our previous serum screens and was shown previously to be a modest affinity ligand for anti-AQP4 autoantibodies.
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