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Despite the recent –omics has offered substantial insights into the diversity and ecophysiology of these bacteria never envisioned before by providing millions of sequence reads at an unprecedented scale, studies based on high-throughput sequencing are still scarce.
For example, Illumina sequencing technology offers millions of sequence reads from a single instrument run.
This database contains millions of sequence reads that have been obtained mostly from biological samples with a particle size of 0.2 to 0.8 µm.
The known porcine miRNAs have a broad range of expression levels, varying from millions of sequence counts for the most abundant to single count miRNAs.
Millions of sequence comparisons are required to find the most conserved regions within gene families and subfamilies, to ensure that probes are selected to span diverse gene sequences that encode similar functions.
The millions of sequence reads were aligned against 414 distinct HIV-1 subtype B genome entries in the public Los Alamos National Labs HIV database (www.hiv.lanl.gov), and the reads that aligned to each reference genome were then used to generate new consensus sequences.
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Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample.
Caporaso, J. G. et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample.
The FPP sequence was derived from a structurally diverse Phylomer phage-display library comprising hundreds of millions of sequences (so-called Phylomers) of microbial and viral genomic origin [41,42,43,44].
Caporaso JG, Lauber CL, Walters WA, Berg-Lyons D, Lozupone CA, Turnbaugh PJ, et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample.
(This type of technology now makes it feasible to sequence the genome of a human for a few thousand dollars). Each of his experiments can generate hundreds of millions of sequences to analyze.
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