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Loci, most difficult to assess with respect to the copy number upon gel-sizing (i.e. containing short repeats of 20 bp size or less, namely VNTR 19, 20 and 24) were sequenced to verify estimates of sequence divergence.
Interestingly, none of the pathways with either elevated or diminished pathway level transcript CV showed significantly different estimates of sequence polymorphism in comparison to randomly generated pathways (Table S5)[52].
This would produce upwardly biased estimates of sequence divergence.
We excluded these substitutions from our estimates of sequence divergence between ancestral and descendant repeat element copies, producing refined estimates of sequence divergence.
These suboptimal alignments may lead to less accurate estimates of sequence divergence.
This would produce upwardly biased estimates of sequence divergence from consensus.
Similar(35)
Comparison with Drosophila and Anopheles databases gave similar results, with estimates of sequences possessing no similarity of 44.7 and 45.9%, respectively.
In addition, some studies have targeted LR testing to very high-risk patients already known to be negative for mutations detected with sequencing, without providing prevalence estimates of sequencing versus LR mutations overall.
Instead, an estimate of sequence identity is obtained at a price and effort far below that of whole genome sequencing.
It is hypothesized that a conservative estimate of sequence errors in bacterial sequences deposited to GenBank today is less than 0.1%.
It is notable also that the lower bound estimate of sequence constraint is far in excess of the quantity of protein-coding sequence (approximately 29 Mb) in avian genomes, implying that the majority of functional sequence in avian genomes is noncoding, probably regulatory, sequence.
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