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Additionally, mesenchymal stem cells appear to counteract glial scar formation, which hinders the migration of axons and dendrites [ 125, 126].
EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system.
This gene is widely expressed and has been implicated in the guidance and migration of axons myoblasts, and leukocytes in vertebrates.
Robo1 has been described to be involved in guidance and migration of axons, myoblasts, and leukocytes in vertebrates (e.g.[ 45- 47] ) but is also expressed in the developing lung [ 48].
The absence of lamina propria OECs at E16.5 in homozygous Sox10 lacZ/lacZ embryos was associated with defasciculation of olfactory axon bundles and inappropriate migration of axons within the lamina propria (Fig. 4A B ).
Maternally provided transcripts also included neurogenic differentiation factors (5 genes), which are involved in neuroepithelial stem cell differentiation and neurogenesis, the synaptic protein and receptor of neurotransmitters neuronal pentraxin-1 precursor (nptx1) and two ephrins and ephrin type-B receptors (4 genes), that play a crucial part in migration of axons.
Similar(54)
Molecular boundaries formed by astrocytes take part in guiding the migration of developing axons and certain neuroblasts [ 186].
In adults, stc expression is highest in ovaries and provides essential maternal contributions to early development: embryos deprived of a maternal source of STC show abnormal development of the ventral nerve cord and misguided migration of motoneuronal axons [ 9].
VAB-8 is a kinesin-like molecule that is essential for the posteriorly directed migration and outgrowth of axons [ 27]; UNC-14 is a RUN-domain containing protein that regulates the subcellular localization of the axon guidance receptor UNC-5 [ 28] and that mediates the kinesin-1-dependent transport of synaptic vesicles [ 29].
Actually, during the last 40 years, awareness is increased of the AChE's role in regulating cell-to-cell communications such as the ones occurring during embryonic development [ 38, 39], for example, inductive processes, morphogenetic cell migrations, regulation of axon growth, and neurogenesis.
Robo1 and -2, members of the roundabout receptor family, are single-transmembrane receptors that respond to secreted slit proteins and act as repellents regulating the migration of neurons and axons, but are also involved in inhibition of leukocyte chemotaxis, tumor angiogenesis and endothelial cell migration [55], [56], [57].
Related(17)
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