Do the movements of axon guidance follow patterns that can be described quantitatively by statistical physics?
The movement of the axon than approximates a random walk.
Using this approach, the precise molecular mechanisms through which UNC-40 becomes localized and through which axon outgrowth takes place is less significant, as stochastic physics simply considers the mass effects that the outgrowth activity has on the movement of the axon at the macroscopic scale.
Indeed, using alternative approaches that do not directly assay movement of APP through axons, others have also concluded that an important route for axonal transport of APP by kinesin-1 may involve calsyntenin-1 (12, 12).
Wang, L. & Brown, A. Rapid movement of microtubules in axons.
Actin remodelling plays a critical role in localized and retrograde movement of mitochondria within axons (Morris and Hollenbeck, 1995; Ligon and Steward, 2000a; Chada and Hollenbeck, 2004).
Notably, the effect of loss of JIP1 on movement of APP through axons of living neurons, and the impact of such loss on APP processing and Aβ production has not been reported.
The relatively long distance (~5 mm) from the infusion site to the mammillary nucleus via the fornix and the normally tightly regulated movement of proteins along axons suggest that the transport of aggregated tau species was probably an active process.
As well as possible mitochondrial defects, it is thought that changes in the composition of the plasma membrane and other intracellular membranes may in turn affect the normal processes responsible for the movement of membranes within axons and dendrites, subsequently leading to accumulation of membranes as so-called spheroids.
Movements of the axon over time were corrected using the AutoAligner software (Bitplane Inc., Zurich, Switzerland) by aligning the oil bubble indicating the injection site.
