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Because we have observed association of CCR2+ macrophage trafficking with tumor cell-produced hBD-3, but not MCP-1, in oral CIS lesions (Figure 2B, 2C; Figure 3B D) and in xenograft tumors in nude mice (Figure 5C E), we hypothesized that hBD-3 mediates monocyte/macrophage migration by acting through CCR2.
In addition, a number of soluble factors have been proposed to play a role in cortical interneuron migration by acting as motogenic factors in vivo.
miR-200 family was found to inhibit cell migration by acting on the transcription factors ZEB1 and ZEB2, which suppress E-cadherin [ 324].
It was shown that catecholamines regulate HSC proliferation and migration by acting either on the niche or on HSCs directly (Katayama et al., 2006; Méndez-Ferrer et al., 2008; Spiegel et al., 2007).
Selection is perhaps inhibiting migration by acting against non-locally adapted genotypes and ultimately favouring traits that would confer advantages under local environmental conditions (Garrant et al. 2005; Postma and Van Noordwijk 2005).
In addition, downregulation of miR-15a and miR-16 in CAFs in the prostate cancer microenvironment promoted tumor growth and progression by suppressing the posttranscriptional repression of Fgf-2 and its receptor Fgfr1, which enhance tumor-cell survival, proliferation, and migration by acting on both stromal and tumor cells [ 50].
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These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway.
The collapse of Libya's government and economy not only changed the equations for migrants, it also created incentives for locals to facilitate their migration to Europe by acting as human traffickers, facing the risks for the promise of incomes they couldn't get otherwise.
Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), the best characterized membrane-anchored MMP, plays essential roles in tumor cell migration and invasion by acting as a potent matrix-degrading protease that digests a broad spectrum of ECM proteins [ 13- 15] as well as a number of cell surface-associated adhesion receptors [ 16, 17].
The plethora of published reports in recent years demonstrated that they play fundamental roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation by acting as tumour suppressor or oncogene, and aberrations in their expressions have been linked to onset and progression of various cancers.
Such bioengineered smart materials may utilize nanomaterials that can stimulate cell division, cell migration and wound healing by acting at genomic or proteomic level to regulate the expression of important biomolecules involved in these events.
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