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Exact(6)
Intracrystalline damage associated with radiation damage (metamictization), particularly within U-rich zircon, can lead to fast-diffusion pathways which allow U, Th and Pb migration at low temperatures [19, 20].
Fifteen of the small molecules were shown to inhibit significantly in vitro CCR4-mediated migration at low concentrations, mediating 50% inhibition of migration at low nanomolar level or below (see Table 2).
In contrast to other constitutive mutants like vinculin-LD that block migration at low expression rates [21], there is no indication for a dominant negative effect of vinculin-ΔEx20 expression on cell migration in the three-dimensional matrix environment.
It was demonstrated that crude aqueous extracts of P. indica root effectively inhibited cancer cell proliferation, focus formation, and migration at low concentrations (100 300 μg/ml).
However, extracellular CyPA has been found to have a biphasic effect, by promoting cell proliferation and migration at low doses and cytotoxic effects at higher doses.
The significant inhibition of endothelial cells migration at low extract concentration (0.5 μg/ml) and the inhibition differentiation of endothelial cells on matrigel indicate these steps in the angiogenesis cascade as possible targets of the P. jiringa active principles.
Similar(54)
The rate of lateral tilt appears to control the style of channel movement, with gradual migration occurring at low tilt rates, and avulsion at higher rates.
The metastatic clone PC3MLN4 exhibited a potent response to treatment in both proliferation and migration even at low dose (1 ng/mL) but showed no reduction in uPAR expression either at the mRNA or protein level.
Alternatively, we should consider the hypothesis of different migration patterns at low vs high altitudes: a higher level of seed flow between districts at high altitudes than at low altitudes.
Muller et al. established that the optimal migration/invasion of MDA-MB231 during SDF-1α treatment was obtained at 100 ng/ml with lower migration and invasion at low and high doses [ 16].
At the same time, apoEdp peptide inhibited HUVEC cell migration and tube formation at low concentrations in a wound-healing/migration assay, Boyden chamber migration assay, and tube formation assays.
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