They may represent myocardial progenitors that have initiated migration at a later time than in a wildtype embryo.
The data again show no significant differences in bacterial binding, or any increased migration at this later time-point.
The theoretical advantage of a stimulating catheter is that if stimulation of the catheter tip with a low charge elicits an appropriate motor response, correct catheter position at the time of stimulation may be assumed, although catheter tip migration at a later stage may of course still occur.
Our measurements suggesting that tangential migration occurs predominantly at later stages of RIN migration are consistent with previous studies using clonal boundary analysis (Reese and Galli-Resta, 2002; Reese et al., 1995, 1999).
This method enables us to introduce genes of interest into VZ progenitor and stem cells of rodent embryos, and to observe resulting phenotypes such as proliferation, migration, and cell morphology at later stages.
Its occurrence among Ashkenazi Jews may be an indicator of admixture that occurred in the Rhine Valley prior to the Ashkenazi Jewish migration to Eastern Europe or at later time points in certain locales (Nebel et al. 2005).
However, we cannot exclude the possibility that cell migration, and in particular migration of neurons, is affected at later stages in development.
Therefore, mTOR deletion may not be sufficient during early stage migration and might become more robust at later stages.
