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The overexpressed and activated PKCγ then promotes cancer cell migration and decreases cancer cell apoptosis.
Over-activation of SRC increases cell growth and survival, as well as promotes cell migration, and decreases cell-matrix adhesion.
These results suggest that loss of DHRS7 promotes cell migration and decreases adhesion in all three cell lines tested.
QSOX1 also reduces the invasive potential of cells by reducing cell migration and decreases the activity of the matrix metalloproteinase, MMP-2, involved in these mechanisms.
Additionally, by applying migration-, scratch- and adhesion assays, we show that IL-6TS increases motility and migration and decreases adhesion of prostate cells facilitating thereby processes that determine metastasis initiation and spread.
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► Reduced macrophage migration and decreased aortic inflammation in ApoE-null mice lacking DGAT1.
The present study revealed that EGCG inhibited the migration and decreased the MMP-2 activity of uveal melanoma cells.
Similarly, Guo and colleagues [ 6] demonstrated increased migration and decreased proliferation upon BMP4 overexpression in MDA-MB-231 and MCF-7 breast cancer cells.
38, 39 Rosiglitazone inhibited endothelial cell proliferation and migration and decreased VEGF-induced tubule formation in human umbilical vein endothelial cells.
Moreover, CM from URG4/URGCP-silenced HCC cells inhibited HUVEC migration and decreased the formation of second- and third-order vessels in the CAM assay.
We have demonstrated that AT-MSCs induced morphological changes, epithelial-to-mesenchymal transition, increased adherence, mammosphere formation, migration and decreased proliferation in SKBR3.
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