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The latter migrate into lymph nodes where they induce Th2-cell commitment.
Concurrent with this maturation event, the DCs migrate into lymph nodes where they can present antigen and stimulate T-cells.
T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites.
The higher CCR7 expression may allow SLE pDCs to migrate into lymph nodes where they could interact with T lymphocytes.
As the activation of T cells occurs in secondary lymphoid organs, the capacity of the ex vivo generated DC to migrate into lymph nodes in vivo appears to be of crucial importance [ 10– 10].
Similar(55)
Our data suggest that upon activation, T cells will not migrate efficiently into lymph nodes and inflamed tissues unless they up-regulate surface CD152.
Additionally, our finding as to the increased accumulation of CCR7−/− Treg cells in the lymph nodes was different from the report that transferred CCR7−/− Treg cells fail to migrate into the lymph nodes and suppress antigen-induced T cell response [23].
In this context, it has been reported that DCs from CCR7−/− mice fail to migrate into the lymph nodes [3], [5].
These may subsequently be activated to migrate into the lymph node to present antigen to T cells.
The activated dendritic cells can migrate into local lymph nodes, leading to acceleration of antigen presentation and TH2 cell activation.
It is hypothesized that dendritic cells are activated by unknown stimuli in peripheral tissues, and migrate into the lymph nodes, where they induce T cells to proliferate.
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