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DC migration into lymph nodes is of critical importance in cancer immunotherapy based on DC [27], [28], [29].
Importantly, CD152 signals also enhanced Th1 cell migration into lymph nodes and a site of cutaneous inflammation in a short term in vivo homing assay.
Thus, our data add an important new piece to the puzzle by showing that CD152 signals license T cells for chemotaxis and migration into lymph nodes and inflammatory sites.
Pathogens such as M. tb can inhibit complete maturation and expressions of co-stimulatory molecules that are necessary for migration into lymph nodes by inducing DCs to produce IL-10 [ 27].
CCR7 and CD62L are essential for migration into lymph nodes, S1P1 regulates T-cell thymic egress and recirculation [ 105], and integrin beta 7 mediates cell recruitment into Peyer's patches and mesenteric lymph nodes [ 106].
Sialomucin (CD43) as well as CD62L is involved in monocyte migration into lymph nodes from the blood by HEVs, and our data would indicate that CD62L is not necessary or largely redundant in monocyte trafficking in the normal mouse, consistent with data from L-selectin deficient mice.
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Binding of high affinity LFA-1 on T cells leads to firm arrest and facilitates transendothelial migration into the lymph node (LN) [17], [18].
CCR7 and CXCR4 are chemokine receptors for regulating dendritic cell function and migration into draining lymph nodes (Kabashima et al. 2007).
Besides preclinical studies [ 51], also electrochemotherapy of human melanoma induced maturation of dendritic cells (DC) and their subsequent migration into draining lymph nodes [ 70].
Furthermore, due to its low spatial distribution, accurate delivery of cells which may be essential for subsequent migration into nearby lymph nodes cannot be properly evaluated using scintigrapy.
Tissue dendritic cells (DCs) are specialized for high antigen capture and migration into draining lymph nodes, where they are essential for activating naïve T cells.
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