Sentence examples for might influence downstream from inspiring English sources

Thus, loss of PERK signaling might influence downstream genetic and/or epigenetic changes favoring hyper-proliferative disorders characteristic of early steps of breast cancer progression.

Several of these genes encode for transcription factors (e.g., Kruppel-like factor 9 [ Klf9]), or proteins involved in signaling cascades that might influence downstream gene expression (Grin2A, PKC, Nell1), suggesting that they might mediate secondary (indirect) effects of NRSF.

Alternatively, the mutation in ERKD334N might differentially influence downstream effector molecules that promote cell proliferation in tissues receptive to cell cycle progression (i.e. the eye and wing) but do not produce a growth response in the fly heart.

Therefore, it is possible that during physiological TCR stimulation, localization of only a small number of Csk molecules is altered and leads to the activation of a small fraction of Lck molecules that would be difficult to detect with current biochemical or imaging methods (Paster et al., 2009; Nika et al., 2010) but might be sufficient to influence downstream signaling.

If indeed a hypothesis on aberrant cell maturation proves significant, effective new therapeutic strategies might alternatively target steps in differentiation in addition to regulate or influence downstream impaired effector molecules like HD-5 and -6.

Studies suggest that early ventilator settings influence downstream outcome of critically ill patients [34].

Social factors may influence downstream citation patterns.

The recycling and degradation of surface receptors, such as EGFR, will influence downstream signaling pathways.