Sentence examples for might improve binding from inspiring English sources

Nevertheless, we had obtained very useful SAR information from screening the three OBOC libraries (Fig. 1 and Table 1): No additional amino acid is needed at the N-terminus of LXY1, but a hydrogen donor residue (or a polar residue) at the C-terminus might improve binding since it can provide additional interaction with adjacent binding pocket.

In the case of GNA synthesis, we thought that a 5-propynyl group in pyrimidine gNTPs might improve binding to the primer/template complex in the active site of polymerase.

Using other methods, such as including repeat-element amplified products with Cot DNA, as well as higher stringency washes, might improve binding specificities.

The authors reasoned that the lipophilicity of HBED-CC might improve binding to PSMA and thus enable positron emission tomography (PET)/CT imaging of prostate carcinoma (PCa) [ 3].

15 Analysis of the structure of imatinib and that of the Abl kinase domain indicated that changes to the structure's part that binds deep into the ATP-binding pocket would be likely to decrease its efficacy, but that modification of the methylpiperazinyl group of imatinib that lies along a partially hydrophobic group on the surface of Abl kinase might improve binding characteristics.

PARalyzer can improve binding site recognition in data sets published.

Likewise, since there is no homology between the CBM2 of E1 with those in C. bescii, swapping the CBM domains of C. bescii cellulases with the CBM2 of E1 might improve the substrate binding versatility of these enzymes.

Moreover, the replacement of F304 by tyrosine results in the phenolic group being sufficiently close to potentially form a hydrogen bond to the nitrogen on the methoxyquinoline group of quinidine, which might improve the efficacy of quinidine binding to F304Y mSlo3.

An alternative view though is that more potent and selective zinc-binding groups might improve MMPI specificity.

However, in contrast to monovalent nanobodies, the affinity of mAbs having two antigen-binding sites per molecule might improve from avidity effects.

Marbach et al. [ 8] furthermore suggest that incorporating additional information such as transcription-factor binding and chromatin modification data or promoter sequences might improve the accuracy of prediction.