In lieu with our prior finding that murine Th2.R cells were relatively resistant to in vivo rapamycin drug therapy [17], we also hypothesized that pre-transplant co-administration of rapamycin might further augment the host Th2 state.
Our results suggest that, in addition to the suppressed cytolytic machinery of the effector cells, thermal stress might further augment the dysfunction of the NK cells by down-regulating their killing ability via increased secretion of immunosuppressive, NKG2DL-carrying tumor exosomes.
The addition of further chemotherapy to concurrent chemoradiotherapy, delivered in a neoadjuvant or adjuvant sequence, might further augment disease control.
Additionally, targeting carriers to macrophages might further augment sterilizing capabilities of antibiotics by directly elevating concentrations within the bacterial niche.
In addition, many forms of disturbance (e.g. fires, floods) could also increase spatial heterogeneity, which might further augment the potential for balancing selection (Levene 1953; Hedrick 1998, 2006).
The recruitment of study subjects apparently devoid of cognitive impairment might further augment the proportion of those with maintained vitamin B12 and folate levels now known to impinge on cognitious performance ([ 44, 45, 53– 53].
