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This occurs because the core of the micelle provides a hydrophobic microenvironment suitable for solubilizing such molecules.

We thus demonstrate a novel platform for transplantation devices, designed to promote an immunoregulatory microenvironment suitable for cell transplantation and autoimmune regulation.

These advances herald a new generation of microfluidics-based approaches designed for specific tissue and organ applications, incorporating microvascular networks, structures for transport and filtration, and a three-dimensional microenvironment suitable for supporting phenotypic cell behavior, tissue function, and implantation and host integration.

This increase in activity creates a bone microenvironment suitable for receiving the neoplastic cells in the niche.

In addition, ECM can bind signal molecules like growth factors, mitogens, chemokines, and cytokines, which makes the tissue microenvironment suitable for cell proliferation, migration, and differentiation.

In both animal models and humans, oestrogen promotes epithelial hyperplasia, metaplasia, and maturation of cervical epithelium, creating a microenvironment suitable for HPV replication (Arbeit et al, 1996; Elson et al, 2000).

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The nanofibrillar structures that underpin self-assembling peptide (SAP) hydrogels offer great potential for the development of finely tuned cellular microenvironments suitable for tissue engineering.

PCL still provided microenvironments suitable for cells to be active yet it seemed to cause de-differentiation (Col1) of chondrocytes inside the scaffold while many cells migrated out, growing cartilage outside the scaffold.

Only the elucidation of the many still unknown aspects of such complex process and the progress in the coculture methods to maintain germ cells for long periods in vitro in 3-D microenvironments, suitable for the different stage-dependent requirements of gametogenesis, will give the necessary tools for rendering the production of germ cells from stem cells a reliable possibility.

The former one mainly includes proteins (i.e., collagens, zein, gelatin, elastin, silk fibroin) amides (i.e., starch) and polysaccharides (i.e., chitin, chitosan, alginates, cellulose derivates), which are macromolecules totally recognized in the biological microenvironment fully suitable for the regeneration of different tissues (i.e., nerve, cartilage, bone).

These data are consistent with previous observations that the in vivo microenvironment is suitable for cellular reprogramming.

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