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In the past few years, analyses of newly sequenced microbial genomes have revealed even more extensive gene jumping.
Several uncultured single microbial genomes have recently been sequenced using the single cell approach [15], [16], [17], [18].
Evaluation of intragenomic variation of the rRNA genes has become possible since more and more sequences of whole microbial genomes have recently become available.
Up to now, thousands of microbial genomes have been published in public databases.
Overall, it is estimated that 1.6 32.6%% of the genes in microbial genomes have been acquired by HGT [ 7].
Hsieh et al. [ 1] investigated the oligonucleotide distributions of typical microbial genomes and found that the microbial genomes have the statistical characteristics of a much shorter DNA sequence.
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Independently of Dr. Keim, however, the Institute for Genomic Research, which specializes in microbial genomes, had been determining the sequence of chemical building blocks in the DNA of the anthrax bacterium.
Genome mining of sequenced microbial genomes has resulted in a wealth of restriction enzymes with new specificities or unique properties (ApeKI (G∧CWGC), PhoI (GG∧CC), CviKI-1 (RG∧CY), NmeAIII (GCCGAG 20 21/18 19) [11], [11], Nt.CviPII (∧CCD) [12]; NEB catalog 2009/10) [1].
Comparison of completely sequenced microbial genomes has revealed how fluid these genomes are.
The total number of paralogs in microbial genomes has been shown to correlate with genome size [ 8].
The availability of microbial genomes has allowed for new and remarkable insights into the evolution of microorganisms.
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