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The critical influence of these factors on microbial exposure is rarely appreciated.

Postnatal microbial exposure is likely to play a greater role in immune maturation and thereby CD development as compared with prenatal microbial exposure [ 35].

Subsequently, as the concept was further explored by specialists in allergy and immunology, it evolved into the broader notion that declining microbial exposure is a major causative factor in the increasing incidence of atopy in recent years.

"The focus on microbial exposure is only one piece of a much larger picture," said Peter Sly, a lung specialist at the Telethon Institute for Child Health Research in Perth, Australia.

The Cox regression models assumes the subjects to be at risk their whole life, even though the marker of microbial exposure is only valid for the first 5 years of life.

If it turns out that more general 'background' exposure is needed, e.g. organisms with low invasiveness or virulence, such as the rapid growing saprophytic strains of Mycobacteria, the idea of 'right' and 'wrong' types of microbial exposure is academic, unless we could engineer the 'right' exposure, without introducing dangerous organisms.

Similar(53)

Better indicators of total quantity and diversity of microbial exposure are needed in studies on the development of asthma.

This diversity is not fully understood, but host genetics, the environment, and early microbial exposure are implicated.

To what extent might cleaning and hygiene, as distinct from other influences on microbial exposure, be a significant factor?

The hygiene hypothesis originally proposed that antibiotic usage and lifestyle alterations that limit microbial exposure were predisposing populations of people in developed countries to autoimmune disease (Strachan, 2000).

We emphasize that immunoregulation by microbial exposures is no longer a 'hypothesis'hypothesis

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