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Many microarray studies so far reported have led to the discovery of several genes associated with BC.
However, few microarray studies so far have addressed developmental toxicity (Docterman and Smith 2002) or embryonic development (Ko 2001; Smith and Greenfield 2003).
In many microarray studies so far, the goal has been to compare two physiological statuses, e.g., disease vs. healthy, by analyzing a single tissue in several individuals.
Most microarray studies so far reported have utilized highly selected patient populations [ 11- 13] and hereditary breast cancer [ 14], and few studies have focused on treatment prediction [ 15].
Development of such a tool will permit biologist to quickly generate different array hybridization loops, compare the cost and experiment design and efficiently design microarray studies so that robust statistical conclusion can be made.
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Both Sost and Dkk1 were expressed at background levels in the microarray study so we utilised quantitative real-time reverse-transcription PCR (qPCR) to accurately measure their transcription levels.
Finally, we will discuss why microarray studies have so far failed to identify new targets, and how we might be able to improve on these results through large-scale genotyping of tumours.
Microarray studies available so far in the area of plant-nematode interactions mostly examined the compatible or susceptible interaction.
Two of the largest childhood ALL microarray studies published so far demonstrated the presence of distinct gene expression patterns in six known prognostic subgroups [ 13, 14].
The lack of genes consistently regulated by high Se in these microarray studies suggests that the genes so far identified may not be useful as Se-specific molecular biomarkers.
The last published microarray study on meningiomas so far was published in 2009 and performed by Castells et al. [ 26].
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