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Hannah Keartland of Cancer Research UK believes the mobile game is the first of its kind.The game was created from the DNA microarray data found in a breast cancer trial by Carlos Calda for Cancer Research UK's Cambridge Institute.
A table showing the position of ChIP peaks relative the differentially expressed genes from the vhl Vs WT microarray data found using GREAT version 2.02.
Comparing these data from real cells with our simulated microarray data found that the datasets were notably different in the spread of expression ratios (Fig. 6).
In silico expression analysis based on microarray data found that approximately 5% of these genes are transcriptionally more active in somatic embryos than in actively dividing callus and non-dividing leaf tissues.
Analysis of microarray data found that TERT was overexpressed in non-endometrioid cancer (P = 0.0015, Fig. 2a), however, this was not observed in the larger TCGA RNASeq dataset (P = 1.0, Fig. 3a).
Our analysis of published tumor microarray data found S1P2 mRNA to be significantly reduced in PDAC (Buchholz et al., 2005; Segara et al., 2005; Badea et al., 2008), and some lung and colon tumors (Bhattacharjee et al., 2001), compared to their corresponding normal tissues.
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Indeed, a meta-analysis of microarray gene expression data found TWIST to be highly expressed in human ILC samples, showing 70% had elevated TWIST mRNA expression, compared with 32% of ductal carcinomas [ 45].
The same study also analyzed microarray data and found that three tumor suppressor gene transcripts were upregulated in φC31-modified cells [12].
From the microarray data, we found a total of 280 genes (about 9% of genome) that showed at least 2-fold change, suggesting that these genes were regulated by droxyR through either direct or indirect mechanisms.
To investigate HBD2 mRNA expression throughout the colon we mined the microarray data and found that the expression of HBD2 mRNA differed according to disease group (figure 1A), inflammation (figure 1B) and location in the colon (figure 1C).
Interestingly, upon direct observation of the microarray data, we found that four of these genes (Mtf-1, DD104, Kaz1, A2M) had intensities over 2 times greater in LPS when compared to controls, but that the overall level of the intensities was rather low and not sufficient to consider the difference between control and LPS-injected to be significant.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com