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In these RNAseq analyses, the basal subtype was used as a surrogate for TNBC; additionally, we found highly similar expression patterns when comparing TNBC with all other biomarker breast cancers using microarray datasets found on Oncomine [ 65] (data not shown).
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4 The combinatorial search does not require a long computational time for most DNA microarray time series datasets found on the web, such as the datasets in the Gene Expression Omnibus 10 and ArrayExpress.
We applied our method to five human brain microarray datasets and found that global gene expression can be used to predict the chronological age of a normal brain sample.
By data mining in microarray datasets we found that expression of DLX2 occurred in 21.6% of patients, and was significantly correlated with prolonged disease-free survival and reduced incidence of relapse.
These were then compared in the same way as the Arabidopsis microarray datasets to find overlap.
We cross-correlated these results with our carbon starvation microarray dataset and found that the expression of a significant number of both cell-cycle regulated and non cell-cycle regulated CtrA targets was altered upon 30 min of carbon starvation (Table 2).
We validate these signatures on genome-wide microarray dataset and found strong association between the expression of these signature genes and pathologic parameters.
To solve this issue, we searched the initial microarray dataset and found most Chrn-subunits to be expressed in the mdDA region (data not shown).
In addition, 6 genes (4 up-regulated: CEACAM1, DDIT3, SCARB2, ZFAND2A; and 2 down-regulated: C9orf19 and RPL5) selected from the HCV clones microarray dataset were found to be modulated in a same way in liver biopsies of patients showing non-CC IL28B polymorphism [ 20].
We also checked enrichment analysis results in the TCGA and EGA microarray datasets, where we found that 24 of the total 28 CEPs (86%) are confirmed by at least one other data set and 15 of them are confirmed in both (Table 3).
Minimum information about a microarray experiment (MIAME) criteria were met [ 56], and the complete microarray datasets described can be found at the National Center for Biotechnology Information Gene Expression Omnibus (accession number: GSE16098).
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