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For these reasons we have used a microarray approach, with two structurally and mechanistically different PAR2 agonists, to clearly establish effects of PAR2 activation on human gene expression.
For studying AS events on a genome-wide scale, a microarray approach, with probes designed for each exon or covering the whole genome, may prove useful.
Additional comparative analyses of gene expression in V. dahliae, under growth conditions that promote or preclude microsclerotial development, were conducted using a microarray approach with RNA derived from V. dahliae strain Dvd-T5, and from the amicrosclerotial vdh1 strain.
In other studies, MARs and SARs of chromosomes 14 18 of HeLa and primary aortic adventitial fibroblasts (AoAF) were compared using a microarray approach with much finer resolution than imaging approaches (Linnemann & Krawetz 2009b; Linnemann et al. 2009).
Additional comparative analyses of gene expression, under growth conditions that promote or preclude microsclerotial development, were conducted using a microarray approach, with RNA derived from V. dahliae strain Dvd-T5 and an amicrosclerotial mutant (vdh1 strain) derived from Dvd-T5 by targeted mutagenesis [ 20].
In this study, we investigated the global expression profile of the stringent response using a DNA microarray approach with the aim to characterize the (p ppGpp-dependent regulatory network, and we also focused on methionine biosynthesis, the sole amino acid whose biosynthesis p ppGpp-dependentolled by stregulatorysponetworkB. suis.
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In many recent reports, the protein microarray approaches with immobilized pathogen-related antigens were used for the parallel detection of relative antibodies in sera [5 8].
In this study, we optimized the identification of methylation markers after pharmacological unmasking microarray approach combined with microarray expression data of primary cancer samples.
The use of this microarray approach, combined with the large sampling size, gives insight to global E. coli diversity on a previously unexplored scale.
Finally, our microarray approach, combined with biological validation, provides an efficient approach to elucidate the regulatory pathways underlying altered expression of antisense transcripts and might uncover important roles for these transcripts in oncogenesis.
Initially, we used a whole genome microarray approach combined with histology and flow cytometry to provide a global and comprehensive assessment of the complexity of the immune networks associated with S. aureus persistent infection.
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